hrp0092p1-190 | Diabetes and Insulin (1) | ESPE2019

Periodontal Disease Relates to Diabetes Control in Children and Adolescents with Type 1 Diabetes

Ports Emilija , Pena Alexia , Allen Gabrielle , Gue Sam , Couper Jennifer

Background: Obese children with and without Type 2 diabetes have periodontal disease that relates to systemic inflammation. There is limited data on periodontal disease in children with Type 1 diabetes (T1D).Aim: We aimed to assess periodontal disease markers and its determinants in children and adolescents with T1D.Materials and Methods: Cross-sectional study including 73 children...

hrp0089fc12.6 | Diabetes and Insulin 2 | ESPE2018

Persistent Beneficial Effects of Metformin in Children and Adolescents with Type 1 Diabetes: Adelaide Metformin Randomized Controlled Trial Follow Up

Maftei Oana , Couper Jennifer , Anderson Jemma , Ricci Peter , Gent Roger , Giles Lynne , Pena Alexia

Puberty is a critical period for the development and acceleration of vascular complications in Type 1 diabetes (T1D). We have shown that metformin in addition to insulin improves vascular smooth muscle function and HbA1c in T1D children over 12 months (1). We aimed to determine if children with T1D who received metformin in a randomized controlled trial (RCT) [Trial registration ACTRN126110001148976] have a sustained vascular function improvement 3 years after ceasing metformi...